Harrer, I have read of complaints with A1680 for subsonic loads w/220gr.
It has been awhile, but I think those who were complaining were trying to get the velocity down so slow, to facilitate extreme noise reduction/suppressor work, that they ran into grouping issues. Ramshot load data doesn't have any load data on subs less than 1,000FPS. It seemed like the common consensus on that site was that H110 would do a better job for their goal. I had no problem with A1680 in my initial work up from subsonic speeds to what I wanted, so, I can't confirm what they were complaining about. Personally, I wouldn't go much lighter than your 180's w/A1680. I believe there are much better calibers suited for 150gr and lighter bullets, just my opinion.
Here is a link to Ramshot 's reload data.
http://www.ramshot.com/wp-content/uploads/2010/09/WesternLoadGuide1-2016_Web-1.pdf
As you can see, ALL loads for A1680 in 300BLK supersonic are COMPRESSED loads. Personally, I had problems compressing A1680 for subs and supers, and after a very long trial and error period gave it up. I just dropped down to just below bullet base for all the projectiles I tried and stayed with the ones that grouped well for my pistol. After casting some linotype Lee 300BLK 230gr?, I found I could get more powder in, than I could with my jacketed 220's and not run into a compressed load problem. Linotype casts lighter than a heavier lead percentage mix, and cool off a a little over 200gr for me, which meets my goal of approx. 1,400fps. That is why I specifically specify that I load 200's+ a few hundred feet faster than subsonic when I publish comments on A1680 and 300BLK.
good luck.